The expanding role of HMG-CoA reductase inhibitors (statins) in the prevention and treatment of ischemic heart disease.
نویسندگان
چکیده
منابع مشابه
Rapid effects of statins: from prophylaxis to therapy for ischemic stroke.
Ischemic stroke is a leading cause of death and disability worldwide and is a major contributor to rising healthcare costs. It has been estimated that in the United States, an individual is afflicted with stroke every 53 seconds with fatality occurring about every 2 minutes. Despite recent advances in the treatment of cardiovascular diseases, the therapeutic options for acute ischemic stroke re...
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Atherosclerosis is a chronic inflammatory disease of multiple etiologies. It is associated with the accumulation of oxidized lipids in arterial lesions leading to coronary heart disease. 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (commonly known as statins) are widely used in cardiovascular disease prevention to lower the cholesterol. The antioxidant activity of HMG-Co...
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Hypercholesterolaemia plays a crucial role in the development of atherosclerotic diseases in general and coronary heart disease in particular. The risk of progression of the atherosclerotic process to coronary heart disease increases progressively with increasing levels of total serum cholesterol or low density lipoprotein (LDL) cholesterol at both the individual and the population level. The s...
متن کاملStatins Enhance Clonal Growth of Late Outgrowth Endothelial Progenitors and Increase Myocardial Capillary Density in the Chronically Ischemic Heart
BACKGROUND Coronary artery disease and ischemic heart disease are leading causes of heart failure and death. Reduced blood flow to heart tissue leads to decreased heart function and symptoms of heart failure. Therapies to improve heart function in chronic coronary artery disease are important to identify. HMG-CoA reductase inhibitors (statins) are an important therapy for prevention of coronary...
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Statins, also known as HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase inhibitors, are the world’s most widely prescribed medications. Approximately 24 million people take statins, with 200 million prescriptions filled in 2009 in the U.S. alone. Rapidly accumulating basic and clinical evidence shows that the beneficial effects of statins on cardiovascular system extend well beyond the...
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عنوان ژورنال:
- Current problems in cardiology
دوره 26 12 شماره
صفحات -
تاریخ انتشار 2001